Decidual NK Cells Alter In Vitro First
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منابع مشابه
Immunopathological Aspects of Decidual Tissues in Women with First-Trimester Recurrent Spontaneous Abortion
Background/objective: Studies of the decidual leukocyte populations in women suffering from spontaneous early pregnancy loss may provide insight into immunpathological aspects and even cast light on the etiology of recurrent spontaneous abortion.Methods: In order to clarify the immunological role of endometrial leukocytes in repetitive abortion of unknown etiology, a comparative analysis of phe...
متن کاملThe Assessment of NK Cytotoxicity and CD56+/CD16+ Phenotype by Flowcytometry in PBL Isolated from Women with Recurrent Spontaneous Abortion
Background: Human peripheral blood NK cells constitutively express CD56 and CD16 antigens. Peripheral blood NK cells seem to be strongly related with decidual NK cells, and may reflect the decidual NK cell functional status. There are varied reports concerning the relationship between NK cell cytotoxicity in women with recurrent spontaneous abortion. Objective: To study NK activity in women wit...
متن کاملDecidual natural-killer-cell interaction with trophoblast: cytolysis or cytokine production?
At the implantation site, the uterine mucosa (decidua) is infiltrated by large numbers of natural killer (NK) cells. These NK cells are in close contact with the invading fetal trophoblast and we have proposed that they might be the effector cells that control the implantation of the allogeneic placenta. Recent characterization of NK cell receptors and their HLA class I ligands has suggested po...
متن کاملCD34+ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells.
Natural killer (NK) cells are the main lymphoid population in the maternal decidua during the first trimester of pregnancy. Decidual NK (dNK) cells display a unique functional profile and play a key role in promoting tissue remodeling, neoangiogenesis, and immune modulation. However, little information exists on their origin and development. Here we discovered CD34(+) hematopoietic precursors i...
متن کاملInterleukin-11 signaling is required for the differentiation of natural killer cells at the maternal-fetal interface.
Interleukin-11 (IL-11) is a multifunctional hematopoietic growth factor that has been implicated in the control of reproduction. Studies on IL-11 receptor-alpha (IL-11R alpha)-deficient mice showed that female mice are infertile due to defective decidualization. In this report, we evaluated the development of decidual cells, immune cells, and the vasculature associated with the implantation sit...
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تاریخ انتشار 2006